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Tsutomu Chiba Selected Research

nardilysin

1/2019Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.
1/2018Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.
1/2017Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach.
1/2014Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes.
5/2012Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α.

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Tsutomu Chiba Research Topics

Disease

80Neoplasms (Cancer)
01/2021 - 01/2002
38Infections
01/2018 - 08/2002
34Inflammation (Inflammations)
03/2017 - 03/2003
27Carcinogenesis
01/2018 - 06/2002
24Stomach Neoplasms (Stomach Cancer)
01/2019 - 08/2002
21Ulcerative Colitis
01/2021 - 01/2006
15Colorectal Neoplasms (Colorectal Cancer)
01/2020 - 08/2004
14Colitis
10/2015 - 04/2002
14Gastritis
08/2014 - 08/2002
14Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
06/2013 - 04/2002
13Autoimmune Pancreatitis
01/2020 - 04/2002
13Hepatocellular Carcinoma (Hepatoma)
11/2017 - 01/2003
12Immunoglobulin G4-Related Disease
05/2020 - 04/2010
10Pancreatitis
01/2019 - 04/2002
10Hemorrhage
03/2013 - 08/2003
9Pancreatic Neoplasms (Pancreatic Cancer)
02/2016 - 03/2004
9Crohn Disease (Crohn's Disease)
12/2014 - 04/2005
8Fibrosis (Cirrhosis)
06/2017 - 09/2006
8Hepatitis C
10/2014 - 05/2007
8Ulcer
07/2014 - 08/2002
8Neoplasm Metastasis (Metastasis)
04/2014 - 01/2004
8Pathologic Constriction (Stenosis)
09/2013 - 05/2003
8Colonic Neoplasms (Colon Cancer)
07/2011 - 01/2004
7Esophageal Squamous Cell Carcinoma
04/2018 - 01/2014
7Hepatitis B
05/2016 - 02/2003
7Chronic Hepatitis C
04/2012 - 09/2002
6Adenocarcinoma
01/2019 - 01/2002
6Hepatitis
07/2015 - 10/2007
6Liver Diseases (Liver Disease)
10/2014 - 09/2002
6Peptic Ulcer (Peptic Ulcers)
07/2014 - 08/2002
5Necrosis
11/2018 - 02/2006
5Disease Progression
04/2018 - 06/2008
5Polyps
09/2011 - 01/2002
5Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
12/2008 - 01/2002
4Sclerosing Cholangitis
01/2020 - 02/2010
4Chronic Hepatitis (Chronic Active Hepatitis)
07/2013 - 05/2007
4Duodenal Ulcer (Curling's Ulcer)
06/2013 - 08/2002
4Biliary Tract Neoplasms (Biliary Tract Cancer)
06/2013 - 06/2007
4Non-Erosive Reflux Disease
03/2013 - 12/2008
3Wounds and Injuries (Trauma)
01/2019 - 01/2016

Drug/Important Bio-Agent (IBA)

39Proteins (Proteins, Gene)FDA Link
01/2021 - 01/2002
30CytokinesIBA
11/2018 - 04/2002
22Cytidine DeaminaseIBA
03/2017 - 02/2007
17Immunoglobulin G (IgG)IBA
01/2021 - 06/2003
16InterferonsIBA
10/2014 - 05/2002
13AntibodiesIBA
01/2021 - 01/2003
13DNA (Deoxyribonucleic Acid)IBA
05/2020 - 09/2004
11Biomarkers (Surrogate Marker)IBA
01/2021 - 06/2003
11NucleotidesIBA
05/2016 - 12/2006
10Immunoglobulins (Immunoglobulin)IBA
07/2018 - 07/2002
9EnzymesIBA
01/2021 - 01/2003
9AntigensIBA
01/2018 - 12/2002
9LigandsIBA
02/2013 - 12/2004
9Messenger RNA (mRNA)IBA
02/2007 - 12/2002
8Interleukin-10 (Interleukin 10)IBA
01/2015 - 04/2002
8InterleukinsIBA
12/2014 - 12/2002
8Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2014 - 04/2005
8Tacrolimus (Prograf)FDA LinkGeneric
02/2012 - 04/2005
7AutoantibodiesIBA
01/2021 - 04/2002
7Hepatitis B Surface Antigens (HBsAg)FDA Link
03/2017 - 02/2003
7Infliximab (Remicade)FDA Link
06/2013 - 01/2008
7Proton Pump InhibitorsIBA
03/2013 - 10/2007
6Insulin-Like PeptidesIBA
10/2015 - 01/2004
6Pharmaceutical PreparationsIBA
01/2015 - 08/2002
6Antiviral Agents (Antivirals)IBA
10/2014 - 12/2007
6Ribavirin (Virazole)FDA LinkGeneric
10/2014 - 03/2008
6Dextran SulfateIBA
07/2013 - 04/2005
6GemcitabineFDA Link
06/2013 - 04/2008
6ThioredoxinsIBA
10/2006 - 09/2005
5SteroidsIBA
05/2020 - 09/2011
5RNA (Ribonucleic Acid)IBA
05/2020 - 12/2006
5nardilysinIBA
01/2019 - 05/2012
5Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
07/2014 - 10/2009
5GastrinsIBA
05/2014 - 12/2003
5Adrenal Cortex Hormones (Corticosteroids)IBA
03/2014 - 10/2003
5Toll-Like Receptors (Toll-Like Receptor)IBA
02/2013 - 09/2005
5Anti-Bacterial Agents (Antibiotics)IBA
01/2013 - 05/2005
5Cyclooxygenase 2 (Cyclooxygenase-2)IBA
09/2011 - 01/2002
5Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
11/2010 - 08/2002
5beta CateninIBA
12/2008 - 06/2002
4Therapeutic UsesIBA
01/2019 - 04/2002
4Transcription Factors (Transcription Factor)IBA
01/2017 - 03/2004
4Peptides (Polypeptides)IBA
03/2016 - 03/2006
4IGF Type 1 Receptor (IGF 1 Receptor)IBA
10/2015 - 01/2004
4CarcinogensIBA
09/2015 - 08/2010
4A-Form DNA (A-DNA)IBA
08/2015 - 12/2008
4Fluorouracil (Carac)FDA LinkGeneric
01/2015 - 01/2008
4Carcinoembryonic AntigenIBA
04/2014 - 07/2009
4Phenobarbital (Luminal)FDA Link
11/2011 - 01/2003
4ProteomeIBA
10/2011 - 05/2009
4Hepatitis B Core AntigensIBA
06/2010 - 02/2003
4Interleukin-4 (Interleukin 4)IBA
09/2008 - 12/2002
3ImmunosorbentsIBA
01/2021 - 01/2006
3LactoferrinIBA
05/2020 - 04/2002
3CeruletideIBA
11/2018 - 04/2006

Therapy/Procedure

49Therapeutics
05/2020 - 01/2002
17Liver Transplantation
06/2017 - 08/2003
11Drug Therapy (Chemotherapy)
02/2016 - 04/2004
5Ligation
01/2006 - 02/2002
4Stents
04/2018 - 09/2003